Uncertainty is a given in a world where change is a constant and the future remains intrinsically unknowable.
Goals and plans at least create the illusion of predictability, and at best can guide us in creating the conditions for what we consider good. They don't remove the certainty of uncertainty. Nothing has the power to do that.
That said, it's more practical and useful to focus instead on ambiguity.
Ambiguity is an unclear way forward in any aspect of life. Amidst the noise and signals, clarity is possible in any context of ambiguity.
We create iterations of clarity by focusing on our interests and questions. Together they guide us well from ambiguity to clarity. No goals and plans needed.